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Structure-based discovery of cellular-active allosteric inhibitors of FAK

Naoki Tomita, Yoko Hayashi, Shinkichi Suzuki, Yoshimasa Oomori, Yoshio Aramaki, Yoshihiro Matsushita, Misa Iwatani, Hidehisa Iwata, Atsutoshi Okabe, Yoshiko Awazu,

Bioorganic & Medicinal Chemistry Letters · 2013 · 56 citations · 27 references

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27

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

Duško llić, Yasuhide Furuta, S. Kanazawa et al. · Nature · 1995 · 1.8K citations

, , +16

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

David D. Schlaepfer, Steven K. Hanks, Tony Hunter et al. · Nature · 1994 · 1.6K citations

, , +16

A General and Efficient Copper Catalyst for the Amidation of Aryl Halides and the <i>N</i>-Arylation of Nitrogen Heterocycles

Artis Klapars, Jon C. Antilla, Xiaohua Huang et al. · Journal of the American Chemical Society · 2001 · 1K citations

, , +11

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 969 citations

, , +14

Expanding Pd-Catalyzed C−N Bond-Forming Processes:  The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions

Xiaohua Huang, Kevin W. Anderson, Danilo Zim et al. · Journal of the American Chemical Society · 2003 · 767 citations

, , +16