Dimethyl Sulfoxide Has an Impact on Epigenetic Profile in Mouse Embryoid Body

Misa Iwatani, Kohta Ikegami, Yuliya Kremenska, +4

Stem Cells

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

Tyler Funnell, Shinya Tasaki, Arusha Oloumi, +33

Nature Communications

Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing

Shinsuke Araki, Ryo Dairiki, Yusuke Nakayama, +5

PLoS ONE

Small Molecule InhibitorsApoptosisRna SplicingCell DeathMolecular Biology +16

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

Yoshinori Ishikawa, Kanae Gamo, Masato Yabuki, +18

Molecular Cancer Therapeutics

Demethylase 1AMixed-phenotype Acute LeukemiaMyeloid NeoplasiaHematological MalignancySignaling Pathway +15

Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability

Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, +23

EMBO Molecular Medicine

Genome‐wide and locus‐specific DNA hypomethylation in G9a deficient mouse embryonic stem cells

Kohta Ikegami, Misa Iwatani, Masako Suzuki, +7

Genes to Cells

Structure-based discovery of cellular-active allosteric inhibitors of FAK

Naoki Tomita, Yoko Hayashi, Shinkichi Suzuki, +14

Bioorganic & Medicinal Chemistry Letters

Drug TargetMedicinePharmacologyRational Drug DesignMolecular Docking +2

Discovery and characterization of novel allosteric FAK inhibitors

Misa Iwatani, Hidehisa Iwata, Atsutoshi Okabe, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryDrug TargetMedicineReceptor Tyrosine KinasePharmacology +1

Discovery of selective ATP-competitive eIF4A3 inhibitors

Masahiro Ito, Misa Iwatani, Yusuke Kamada, +7

Bioorganic & Medicinal Chemistry

Drug TargetBiochemistryMedicineNatural SciencesDrug Development +3

T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice

Satoru Matsuda, Rina Baba, Hideyuki Oki, +14

Neuropsychopharmacology

Specific InhibitorMedicineImmunologyNeuroscienceLsd1 Enzyme Activity +2