A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

Masanori Baba, Osamu Nishimura, Naoyuki Kanzaki, +9

Proceedings of the National Academy of Sciences

Discovery of Novel, Potent, and Selective Small-Molecule CCR5 Antagonists as Anti-HIV-1 Agents:  Synthesis and Biological Evaluation of Anilide Derivatives with a Quaternary Ammonium Moiety

Mitsuru Shiraishi, Yoshio Aramaki, Masaki Seto, +8

Journal of Medicinal Chemistry

Lead CompoundsCho/ccr5 CellsLead IdentificationAntiviral DrugChemical Biology +17

Chemical characterization of spider toxin, JSTX and NSTX.

Yoshio Aramaki, Tadashi Yasuhara, Tsutomu Higashijima, +4

Proceedings of the Japan Academy Series B

Microbial ToxinToxinologyBiochemistryNatural SciencesBioanalysis +5

Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety

Masaki Seto, Naoki Miyamoto, Katsuji Aikawa, +5

Bioorganic & Medicinal Chemistry

MedicineActive Ccr5 Antagonists1-Benzazepine DerivativesAntiviral Drug DevelopmentAntiviral Drug +5

Highly Potent and Orally Active CCR5 Antagonists as Anti-HIV-1 Agents:  Synthesis and Biological Activities of 1-Benzazocine Derivatives Containing a Sulfoxide Moiety

Masaki Seto, Katsuji Aikawa, Naoki Miyamoto, +7

Journal of Medicinal Chemistry

Pharmaceutical Science1-Benzazocine DerivativesChemical ModificationPharmacotherapyAntiviral Drug +16

Synthesis of spider toxin (JSTX-3) and its analogs

Yuichi Hashimoto, Yasuyuki Endo, Koichi Shudo, +3

Tetrahedron Letters

Microbial ToxinBiosynthesisEngineeringToxinologyBiochemistry +5

Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

Tomohiro Okawa, Yoshio Aramaki, Mitsuo Yamamoto, +11

Journal of Medicinal Chemistry

Structure-based discovery of cellular-active allosteric inhibitors of FAK

Naoki Tomita, Yoko Hayashi, Shinkichi Suzuki, +14

Bioorganic & Medicinal Chemistry Letters

Drug TargetMedicinePharmacologyRational Drug DesignMolecular Docking +2

Orally Active CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Activity of 1-Benzothiepine 1,1-Dioxide and 1-Benzazepine Derivatives Containing a Tertiary Amine Moiety

Masaki Seto, Yoshio Aramaki, Tomohiro Okawa, +7

Chemical and Pharmaceutical Bulletin

Discovery and characterization of novel allosteric FAK inhibitors

Misa Iwatani, Hidehisa Iwata, Atsutoshi Okabe, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryDrug TargetMedicineReceptor Tyrosine KinasePharmacology +1