Tsutomu Higashijima

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

Tsutomu Higashijima, Sonoko Uzu, Terumi Nakajima et al. · Journal of Biological Chemistry · 1988 · 679 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

Tsutomu Higashijima, John P. Burnier, Elliott M. Ross · Journal of Biological Chemistry · 1990 · 602 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

Tsutomu Higashijima, K M Ferguson, Paul C. Sternweis et al. · Journal of Biological Chemistry · 1987 · 366 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.

Gabriel Berstein, Jonathan L. Blank, Alan V. Smrcka et al. · Journal of Biological Chemistry · 1992 · 344 citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.

Eric M. Parker, Kimihiko Kameyama, Tsutomu Higashijima et al. · Journal of Biological Chemistry · 1991 · 283 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15