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Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure–activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1

Pharmacokinetic PropertiesMolecular PharmacologyPharmaceutical ScienceMetabolic StabilityBiochemistryMedicineNatural SciencesChemical BiologyPharmacologyPharmaceutical ChemistrySynthetic ChemistryDrug DiscoverySubstituted Lactams