Concepedia

Metabolic Stability Modulation

Metabolic Stability Modulation is a bioisosteric strategy that systematically alters the metabolic resistance of a compound by modifying its electronic and steric properties through the strategic substitution of functional groups or atoms to influence enzymatic degradation rates.

226

Publications

10.5K

Citations

1.9K

Authors

435

Institutions

Publications per year

2017–2026

75

Parents

Publications

226

An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

Christian E. Schafmeister, Julia Po, Gregory L. Verdine · Journal of the American Chemical Society · 2000 · 1K citations

, , +13

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

Nhan van Tran, Felix G.M. Ernst, Ben R Hawley et al. · Nucleic Acids Research · 2019 · 486 citations · Full text

, , +17

Shelf-Stable Electrophilic Reagents for Trifluoromethylthiolation

Xinxin Shao, Chunfa Xu, Long Lü et al. · Accounts of Chemical Research · 2015 · 407 citations

, , +13

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

Carolyn F. Deacon, Lotte Bjerre Knudsen, Kjeld Madsen et al. · Diabetologia · 1998 · 305 citations · Full text

, , +14

The SUMO protease SENP5 is required to maintain mitochondrial morphology and function

Rodolfo Zunino, Peter Rippstein, Miguel A. Andrade‐Navarro et al. · Journal of Cell Science · 2007 · 263 citations

, , +17

1–5 of 226

Authors

1.9K

  1. JG
    John Gatfield

    Actelion (Switzerland), Switzerland

    3 publications · 240 citations

    3

    h-index

  2. TB
    Tomasz Bączek

    Gdańsk Medical University, Poland

    3 publications · 92 citations

    3

    h-index

  3. GH
    Gyoonhee Han

    Yonsei University, South Korea

    3 publications · 69 citations

    3

    h-index

  4. MC
    Misun Cho

    Yonsei University, South Korea

    3 publications · 69 citations

    3

    h-index

  5. MK
    Mark Kudolo

    University of Tübingen, Germany

    3 publications · 53 citations

    3

    h-index

1–5 of 1.9K

Institutions

435

  1. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    61 publications

    3.6K citations

  2. Pfizer (United States)

    New York, United States

    8 h-index

    67 publications

    3.1K citations

  3. Bristol-Myers Squibb (United States)

    New York, United States

    7 h-index

    113 publications

    3.7K citations

  4. National Institutes of Health

    Bethesda, United States

    5 h-index

    10 publications

    287 citations

  5. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    12 publications

    1.8K citations

  6. Roche (Switzerland)

    Basel, Switzerland

    4 h-index

    10 publications

    1.9K citations

  7. Goethe University Frankfurt

    Frankfurt am Main, Germany

    4 h-index

    15 publications

    212 citations

  8. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    3 h-index

    6 publications

    371 citations

1–8 of 435

Venues

  1. Journal of Medicinal Chemistry

    41 publications · 2.2K citations

    26

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    23 publications · 485 citations

    15

    h-index

  3. European Journal of Medicinal Chemistry

    15 publications · 504 citations

    15

    h-index

  4. Bioorganic & Medicinal Chemistry

    11 publications · 310 citations

    10

    h-index

  5. ChemMedChem

    8 publications · 336 citations

    8

    h-index

1–5