Metabolic Stability

Metabolic stability is a pharmacokinetic property that characterizes a drug's resistance to biotransformation and degradation by hepatic and extrahepatic metabolic enzymes.

6.3K

Publications

367.1K

Citations

29.5K

Authors

4.7K

Institutions

Publications per year

2017–2026

946

Variants

Metabolic Stability Studies

Parents

Medicinal Chemistry

Children

Biotransformation PathwaysCytochrome P450 EnzymesDrug-drug Interaction RiskEnzyme InductionEnzyme InhibitionFirst-pass MetabolismHepatocyte StabilityIn Vitro Metabolic AssaysIntrinsic ClearanceMetabolic Hot Spots

Publications

6.3K

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

Allan G. Gornall, Charles J. Bardawill, Maxima M. David · Journal of Biological Chemistry · 1949 · 16.2K citations · Full text

Life Sciences, Biochemistry, Clinical Biochemistry +9

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

Masafumi Matsuda, Ralph A. DeFronzo · Diabetes Care · 1999 · 5.6K citations

Medicine, Endocrinology, Internal Medicine +12

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

L J Ignarro, Georgette M. Buga, K S Wood et al. · Proceedings of the National Academy of Sciences · 1987 · 5.1K citations · Full text

Medicine, Pharmacology, Physiology +12

Metabolic stability and epigenesis in randomly constructed genetic nets

Stuart Kauffman · Journal of Theoretical Biology · 1969 · 4.9K citations

Life Sciences, Biology, Systems Biology +10

Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans

Arie Katz, Sridhar Nambi, Kieren J. Mather et al. · The Journal of Clinical Endocrinology & Metabolism · 2000 · 3.8K citations · Full text

Medicine, Endocrinology, Internal Medicine +9

1–5 of 6.3K

Authors

29.5K

GM
Gerald M. Reaven
Stanford University, United States
22 publications · 2.8K citations
18
h-index
AA
Adnan A. Kadi
King Saud University, Saudi Arabia
17 publications · 499 citations
15
h-index
MW
Mohamed W. Attwa
King Saud University, Saudi Arabia
18 publications · 524 citations
15
h-index
TM
Thomas M. van Gulik
Amsterdam UMC Location University of Amsterdam, Netherlands
13 publications · 588 citations
13
h-index
TR
Thomas Reiberger
Medical University of Vienna, Austria
12 publications · 636 citations
12
h-index

1–5 of 29.5K

Institutions

4.7K

1–8 of 4.7K

Venues

Diabetes Care
142 publications · 22.6K citations
70
h-index
Biochemistry
180 publications · 10.7K citations
60
h-index
Journal of Biological Chemistry
JBC · 130 publications · 25.5K citations
56
h-index
PubMed
Repository · 374 publications · 12.3K citations
54
h-index
Clinical Chemistry
167 publications · 10K citations
53
h-index

1–5

See also Metabolic Stability
Evaluation	High-throughput Screening Intrinsic Clearance Mouse Liver Microsomes Rat Liver Microsomes Liver S9 Fraction Assays Radioactive Half-life Liquid Chromatography-mass Spectrometry Plasma Stability Assays
Determinants	Cytochrome P450 Enzymes Amino Acid Composition Secondary Structure Propensity Hydrophobicity Polarities
Core Methods	Support Vector Machines Liver S9 Fraction Assays Liquid Chromatography-mass Spectrometry Density Functional Theory Quantitative Structure-activity Relationships Graph Neural Networks Graph Contrastive Learning K-nearest Neighbors Naive Bayes Bayesian Modeling
Optimization Strategies	Site-specific Metabolic Blocking Lipophilicity Optimization Metabolic Stability Modeling
Applications	High-throughput Screening Lead Optimization Pharmacokinetic Modeling Reaction-based Molecular Design