Concepedia

Hepatocyte Stability

Hepatocyte Stability is a biochemical assay metric that quantifies the intrinsic metabolic lability of a compound in isolated liver cells, distinguishing it from other stability measures by its exclusive reliance on hepatic cellular systems to predict in vivo hepatic extraction and clearance.

643

Publications

36.4K

Citations

3.3K

Authors

919

Institutions

Publications per year

2017–2026

93

Variants

Hepatocyte Stability StudiesStability In Hepatocytes

Parents

Children

Publications

643

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch, Helmuth Gehart, Ruben van Boxtel et al. · Cell · 2014 · 1.6K citations · Full text

, , +17

Heparin protects basic and acidic FGF from inactivation

Denis Gospodarowicz · Journal of Cellular Physiology · 1986 · 857 citations

, , +5

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

Catherine C. Bell, Delilah Hendriks, Sabrina Moro et al. · Scientific Reports · 2016 · 708 citations · Full text

, , +17

Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

Walter M.A. Westerink, W.G.E.J. Schoonen · Toxicology in Vitro · 2007 · 525 citations

, , +16

Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type

Christiane Guguen‐Guillouzo, Bruno Clément, Georges Baffet et al. · Experimental Cell Research · 1983 · 513 citations

, , +13

1–5 of 643

Authors

3.3K

  1. ML
    Martin L. Yarmush

    Massachusetts General Hospital, United States

    18 publications · 1.4K citations

    17

    h-index

  2. MT
    Mehmet Toner

    Massachusetts General Hospital, United States

    14 publications · 974 citations

    14

    h-index

  3. AP
    Albert P. Li

    In Vitro Admet Laboratories (United States), United States

    10 publications · 867 citations

    10

    h-index

  4. RG
    Ronald G. Tompkins

    Massachusetts General Hospital, United States

    9 publications · 542 citations

    9

    h-index

  5. LR
    Lysiane Richert

    Hôpital d'Hautepierre, France

    9 publications · 655 citations

    9

    h-index

1–5 of 3.3K

Institutions

919

  1. Massachusetts General Hospital

    Boston, United States

    22 h-index

    125 publications

    9.6K citations

  2. Harvard University

    Cambridge, United States

    21 h-index

    113 publications

    8.3K citations

  3. Inserm

    Paris, France

    17 h-index

    75 publications

    7.6K citations

  4. Shriners Hospitals for Children - Erie

    Erie, United States

    14 h-index

    57 publications

    3.7K citations

  5. Rutgers, The State University of New Jersey

    New Brunswick, United States

    13 h-index

    27 publications

    1.5K citations

  6. Karolinska Institutet

    Stockholm, Sweden

    11 h-index

    36 publications

    12.4K citations

  7. University of Pittsburgh

    Pittsburgh, United States

    10 h-index

    27 publications

    2.9K citations

  8. The University of Tokyo

    Tokyo, Japan

    10 h-index

    43 publications

    2.7K citations

1–8 of 919

Venues

  1. Cell Transplantation

    24 publications · 920 citations

    20

    h-index

  2. PubMed

    Repository · 20 publications · 1.1K citations

    16

    h-index

  3. Hepatology

    18 publications · 1.3K citations

    16

    h-index

  4. Journal of Biological Chemistry

    JBC · 15 publications · 946 citations

    15

    h-index

  5. Cryobiology

    18 publications · 641 citations

    15

    h-index

1–5