Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Catherine C. Bell, Anita C. A. Dankers, Volker M. Lauschke, +19

Toxicological Sciences

Tissue EngineeringEngineeringSandwich ConfigurationPathologyCell Culture +18

Isolation and Culture of Primary Human Hepatocytes

Edward L. LeCluyse, Eliane Alexandre, Geraldine A. Hamilton, +4

Humana Press eBooks

PathologyCell CultureSpecies DifferencesHepatobiliary TumorHepatotoxicity +18

Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes

Lysiane Richert, Delphine Binda, Geraldine A. Hamilton, +6

Toxicology in Vitro

HepatologyLiver PhysiologyPhysiologyLipid PeroxidationCell Culture +12

GENE EXPRESSION IN HUMAN HEPATOCYTES IN SUSPENSION AFTER ISOLATION IS SIMILAR TO THE LIVER OF ORIGIN, IS NOT AFFECTED BY HEPATOCYTE COLD STORAGE AND CRYOPRESERVATION, BUT IS STRONGLY CHANGED AFTER HEPATOCYTE PLATING

Lysiane Richert, Michael J. Liguori, Catherine Abadie, +4

Drug Metabolism and Disposition

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

Rowena Sison‐Young, Volker M. Lauschke, Esther Johann, +20

Archives of Toxicology

Cell HealthImmunologyPathologyToxicological MechanismNew Drug +23

Cryopreservation of adult human hepatocytes obtained from resected liver biopsies

E. Alexandre, Catherine Viollon‐Abadie, P David, +8

Cryobiology

HepatologyLiver PhysiologyPhysiologyHepatitisOrgan Preservation +7

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

Sagnik Chatterjee, Lysiane Richert, Patrick Augustijns, +1

Toxicology and Applied Pharmacology

HepatologyDrug-induced CholestasisBiliary TractMedicineLiver Physiology +5

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

Rowena Sison‐Young, Dimitra Mitsa, Rosalind E. Jenkins, +12

Toxicological Sciences

Drug DispositionCell CultureNew DrugSingle Cell SequencingHepatotoxicity +22

Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells

Audrey Baze, C. Parmentier, Delilah Hendriks, +6

Tissue Engineering Part C Methods

Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures

Dumrongsak Pekthong, Nadège Blanchard, Catherine Abadie, +6

Chemico-Biological Interactions

Andrographis Paniculata ExtractHepatologyBiochemistryMedicineLiver Physiology +13