Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

Allan H. Conney · PubMed · 1982 · 1.6K citations

Medicine, Biochemistry, Toxicology +16

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

Tsutomu Shimada, Carrie L. Hayes, Hiroshi Yamazaki et al. · PubMed · 1996 · 795 citations

Pharmacy, Biochemistry, Toxicology +17

COMPARISON OF PRIMARY HUMAN HEPATOCYTES AND HEPATOMA CELL LINE HEPG2 WITH REGARD TO THEIR BIOTRANSFORMATION PROPERTIES

Stefan Wilkening, Frank Stahl, Augustinus Bader · Drug Metabolism and Disposition · 2003 · 771 citations

Pharmacy, Molecular Biology, Toxicology +17

Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

Jodi M. Maglich, Catherine M. Stoltz, Bryan Goodwin et al. · Molecular Pharmacology · 2002 · 652 citations

Medicine, Pharmacology, Toxicology +16

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

Peter J. O’Brien, William Irwin, Dolores Diaz et al. · Archives of Toxicology · 2006 · 609 citations

Pharmacy, Pharmacology, Toxicology +16