High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

Peter J. O’Brien, William Irwin, Dolores Diaz, +9

Archives of Toxicology

HepatologyHealth SciencesMedicineLiver PhysiologyDrug-induced Human Hepatotoxicity +11

A Novel Tankyrase Small-Molecule Inhibitor Suppresses <i>APC</i> Mutation–Driven Colorectal Tumor Growth

Ted Lau, Emily Chan, Marinella Callow, +15

Cancer Research

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

Danna Jennings, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, +36

Science Translational Medicine

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

Todd Logan, Matthew Simon, Gerald Maxwell Cherf, +49

Cell

Neurodegenerative DiseasesMolecular NeuroscienceLysosomal Storage DisorderNeurological DisorderDegenerative Disease +9

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

Julie C. Ullman, Annie Arguello, Jennifer A. Getz, +43

Science Translational Medicine

Molecular NeuroscienceBlood–brain BarrierMedicineEnzyme Transport VehicleMolecular Neurobiology +13

Discovery of (<i>S</i>)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1<i>H</i>-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1<i>H</i>)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development

James F. Blake, Michael Burkard, Jocelyn Chan, +28

Journal of Medicinal Chemistry

Erk Kinase ActivityCellular PharmacologyTumor BiologyPre-clinical PharmacologyMolecular Pharmacology +18

Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X_L Inhibitor

Le Wang, George Doherty, Andrew S. Judd, +31

ACS Medicinal Chemistry Letters

Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index &lt; 1

Yu Zhong, Paula Katavolos, Tien‐Trung Nguyen, +9

Toxicologic Pathology

Gastrointestinal PharmacologyGastroenterologyPathologyWnt SignalingDigestive Tract +14

<scp>LRRK2</scp> Inhibition by <scp>BIIB122</scp> in Healthy Participants and Patients with Parkinson's Disease

Danna Jennings, Sarah Huntwork‐Rodriguez, Maurits F. J. M. Vissers, +19

Movement Disorders

Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells

Dolores Diaz, Andrew D. Scott, Paul L. Carmichael, +2

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Immunocytochemical TechniqueMedicineBioanalysisHistopathologyPathology +7