Anastasia G. Henry

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Anastasia G. Henry, Soheil Aghamohammadzadeh, Harry Samaroo et al. · Human Molecular Genetics · 2015 · 243 citations · Full text

Mitophagy, Atp13a2 Expression, Molecular Biology +21

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

Danna Jennings, Sarah Huntwork‐Rodriguez, Anastasia G. Henry et al. · Science Translational Medicine · 2022 · 230 citations

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

Todd Logan, Matthew Simon, Gerald Maxwell Cherf et al. · Cell · 2021 · 210 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Lysosomal Storage Disorder +11

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

Julie C. Ullman, Annie Arguello, Jennifer A. Getz et al. · Science Translational Medicine · 2020 · 194 citations

Molecular Neuroscience, Blood–brain Barrier, Medicine +15

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

Marco A. S. Baptista, Kalpana Merchant, Ted Barrett et al. · Science Translational Medicine · 2020 · 123 citations