Emily Chan

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

Dirk B. Mendel, Alexander Laird, Xiaohua Xin et al. · PubMed · 2003 · 2K citations

Medicine, Oncology, Pharmacology +15

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

George Thomas, Chris Tran, Ingo K. Mellinghoff et al. · Nature Medicine · 2005 · 605 citations

Medicine, Cancer Biology, Oncology +14

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

James G. Christensen, Randall Schreck, Jon Burrows et al. · PubMed · 2003 · 497 citations

Medicine, Oncology, Pharmacology +15

A Novel Tankyrase Small-Molecule Inhibitor Suppresses <i>APC</i> Mutation–Driven Colorectal Tumor Growth

Ted Lau, Emily Chan, Marinella Callow et al. · Cancer Research · 2013 · 320 citations

Medicine, Oncology, Pharmacology +17

CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation

Venkateswaran Subramaniam, Isabella R. Vincent, H. Allen Gardner et al. · Experimental and Molecular Pathology · 2007 · 63 citations

Life Sciences, Cell Biology, Molecular Biology +15