Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

Molecular determinants of resistance to antiandrogen therapy

Charlie D. Chen, Derek S. Welsbie, Chris Tran et al. · Nature Medicine · 2003 · 2.3K citations

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

Hua Zhong, Kelly A. Chiles, David M. Feldser et al. · PubMed · 2000 · 1.5K citations

Life Sciences, Cell Biology, Oncology +17

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

Erik Laughner, Panthea Taghavi, Kelly A. Chiles et al. · Molecular and Cellular Biology · 2001 · 1.3K citations · Full text

Life Sciences, Cell Biology, Oncology +17

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Christine C. Hudson, Mei Liu, Gary G. Chiang et al. · Molecular and Cellular Biology · 2002 · 1.2K citations · Full text

Medicine, Oncology, Pharmacology +15