Walter M.A. Westerink

Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

Walter M.A. Westerink, W.G.E.J. Schoonen · Toxicology in Vitro · 2007 · 519 citations

Oxidative Stress, Hepatotoxicity, Metabolism +16

Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

Walter M.A. Westerink, W.G.E.J. Schoonen · Toxicology in Vitro · 2007 · 213 citations

Hepatology, Biochemistry, Medicine +10

Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells.

W.G.E.J. Schoonen, Jeroen A.D.M. de Roos, Walter M.A. Westerink et al. · Toxicology in Vitro · 2005 · 130 citations

Cytotoxic Effects, Medicine, Cellular Pharmacology +5

Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I Mechanistic assays on ROS, glutathione depletion and calcein uptake

W.G.E.J. Schoonen, Walter M.A. Westerink, Jeroen A.D.M. de Roos et al. · Toxicology in Vitro · 2005 · 119 citations

Mechanistic Assays, Biochemistry, Medicine +10

Evaluation of the Vitotox™ and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development

Walter M.A. Westerink, Joe C.R. Stevenson, Annick Lauwers et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2009 · 74 citations

Preclinical Drug Evaluation, Radarscreen Assays, Drug Discovery +9