Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

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Pharmacy, Molecular Biology, Toxicology +17

Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

Jodi M. Maglich, Catherine M. Stoltz, Bryan Goodwin et al. · Molecular Pharmacology · 2002 · 652 citations

Medicine, Pharmacology, Toxicology +16

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

Peter J. O’Brien, William Irwin, Dolores Diaz et al. · Archives of Toxicology · 2006 · 609 citations

Pharmacy, Pharmacology, Toxicology +16

Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

Walter M.A. Westerink, W.G.E.J. Schoonen · Toxicology in Vitro · 2007 · 525 citations

Medicine, Biochemistry, Pharmacology +16

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

Cristina Rodríguez‐Antona, M. Teresa Donato, Alan R. Boobis et al. · Xenobiotica · 2002 · 417 citations

Medicine, Biochemistry, Molecular Biology +12