Kjeld Madsen

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

Jesper Lau, Paw Bloch, Lauge Schäffer et al. · Journal of Medicinal Chemistry · 2015 · 959 citations · Full text

Albumin Affinity, Glycobiology, Peptide Science +19

Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration

Lotte Bjerre Knudsen, Per F. Nielsen, Per Olaf Huusfeldt et al. · Journal of Medicinal Chemistry · 2000 · 681 citations · Full text

Peptide Engineering, Glycobiology, Once Daily Administration +21

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

Carolyn F. Deacon, Lotte Bjerre Knudsen, Kjeld Madsen et al. · Diabetologia · 1998 · 299 citations · Full text

Improved Biological Activity, Metabolic Stability, Biochemistry +10

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

S. Runge, Henning Thøgersen, Kjeld Madsen et al. · Journal of Biological Chemistry · 2008 · 290 citations · Full text

Crystal Structure, Molecular Modeling, Signal Transduction +13

Structure−Activity and Protraction Relationship of Long-Acting Glucagon-like Peptide-1 Derivatives:  Importance of Fatty Acid Length, Polarity, and Bulkiness

Kjeld Madsen, Lotte Bjerre Knudsen, Henrik Agersoe et al. · Journal of Medicinal Chemistry · 2007 · 239 citations