Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

Jesper Lau, Paw Bloch, Lauge Schäffer, +14

Journal of Medicinal Chemistry

Albumin AffinityGlycobiologyPeptide SciencePeptide TherapeuticsPharmacotherapy +17

Structure of the human glucagon class B G-protein-coupled receptor

Fai Siu, Min He, Chris de Graaf, +13

Nature

Signal TransductionMolecular PhysiologyG Protein-coupled ReceptorFunctional SelectivityReceptor (Biochemistry) +4

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

S. Runge, Henning Thøgersen, Kjeld Madsen, +2

Journal of Biological Chemistry

Crystal StructureMolecular ModelingSignal TransductionBiochemistryG Protein-coupled Receptor +11

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

Gaojie Song, Dehua Yang, Yuxia Wang, +19

Nature

Allosteric ModulatorsSignal TransductionMolecular PhysiologyG Protein-coupled ReceptorNatural Sciences +7

Small-molecule agonists for the glucagon-like peptide 1 receptor

Lotte Bjerre Knudsen, Dan Kiel, Min Teng, +19

Proceedings of the National Academy of Sciences

Rat PancreasGlycobiologyInsulin SignalingGastrointestinal Peptide HormoneMolecular Pharmacology +18

Structure of the full-length glucagon class B G-protein-coupled receptor

Haonan Zhang, Anna Qiao, Dehua Yang, +30

Nature

Signal TransductionBiochemistryG Protein-coupled ReceptorNatural SciencesReceptor (Biochemistry) +1

Sequential Functionalisation of Bis-Protected Tetrathiafulvalene-dithiolates

Klaus B. Simonsen, Niels Svenstrup, Jesper Lau, +4

Synthesis

Sequential FunctionalisationBis-protected Starting MaterialsEngineeringCaesium Hydroxide MonohydrateOrganic Chemistry +5

Binding Studies between Tetrathiafulvalene Derivatives and Cyclobis(paraquat-<i>p</i>-phenylene)

Mogens Brøndsted Nielsen, Jan O. Jeppesen, Jesper Lau, +5

The Journal of Organic Chemistry

Organic Charge-transfer CompoundInorganic ChemistryTtf DerivativesEngineeringBiochemistry +11

Structure of the glucagon receptor in complex with a glucagon analogue

Haonan Zhang, Anna Qiao, Linlin Yang, +19

Nature

Molecular PhysiologySignal TransductionBiochemistryG Protein-coupled ReceptorNatural Sciences +7

Discovery and SAR of a Novel Selective and Orally Bioavailable Nonpeptide Classical Competitive Inhibitor Class of Protein-Tyrosine Phosphatase 1B

Henrik Sune Andersen, Ole H. Olsen, Lars Iversen, +17

Journal of Medicinal Chemistry

Drug TargetSelective Ptp1b InhibitorsProtein-tyrosine Phosphatase 1BChemical BiologyMedicinal Chemistry +14