Bibia Heidmann

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

Amélie Le Bihan, Ruben de Kanter, Íñigo Angulo‐Barturen et al. · PLoS Medicine · 2016 · 69 citations · Full text

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies

Olivier Bezençon, Bibia Heidmann, Romain Siegrist et al. · Journal of Medicinal Chemistry · 2017 · 58 citations · Full text

Generalized Epilepsies, Pharmaceutical Science, Compound 66B +18

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders

Christoph Boss, John Gatfield, Christine Brotschi et al. · ChemMedChem · 2020 · 47 citations

Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT‐462206: a Potent, Brain‐Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist

Christoph Boss, Catherine Roch‐Brisbare, Michel A. Steiner et al. · ChemMedChem · 2014 · 40 citations

Structure–activity Relationship, Receptor Antagonist, Pharmacotherapy +24

Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2

Thierry Sifferlen, Amandine Boller, Audrey Chardonneau et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 33 citations · Full text

Sleep Disorders, Sleep, Sleep Medicine +9