Ruben de Kanter

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

Inge A.M. de Graaf, Peter Olinga, Marina H. de Jager et al. · Nature Protocols · 2010 · 408 citations · Full text

Pharmacy, Pharmacology, Toxicology +10

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Andreas Weiss, Edwige Lorthiois, Louise Barys et al. · Cancer Discovery · 2022 · 134 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Stéphane Ferretti, Jacques Hamon, Ruben de Kanter et al. · Nature · 2024 · 113 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Comparison of five incubation systems for rat liver slices using functional and viability parameters

Peter Olinga, Kees Groen, Ingrid H. Hof et al. · Journal of Pharmacological and Toxicological Methods · 1997 · 108 citations

Medicine, Biochemistry, Hepatology +4

COMPARISON OF MOUSE AND RAT CYTOCHROME P450-MEDIATED METABOLISM IN LIVER AND INTESTINE

Marcella Martignoni, Geny M. M. Groothuis, Ruben de Kanter · Drug Metabolism and Disposition · 2006 · 101 citations · Full text

Medicine, Biochemistry, Pharmacology +16