Concepedia

Edwige Lorthiois

EL

24

Publications

1K

Citations

19

H-Index

1995

Active since

Affiliations

Novartis (Switzerland)(Current)

Novartis (United States)

Laboratoire de Chimie Organique

Novartis Institutes for BioMedical Research

Pfizer (United States)

Edwige Lorthiois is an author at Novartis (Switzerland) specializing in medicine, drug discovery, and pharmacology.

ORCID

Top concepts

Publications per year

1995–2022

24

Publications

24

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Andreas Weiss, Edwige Lorthiois, Louise Barys et al. · Cancer Discovery · 2022 · 130 citations · Full text

A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate

Ulrich Hassiepen, Ulf Eidhoff, Gabriele Meder et al. · Analytical Biochemistry · 2007 · 110 citations

, , +8

JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS<sup>G12C</sup> for the Treatment of Solid Tumors

Edwige Lorthiois, Marc Gerspacher, Kim S. Beyer et al. · Journal of Medicinal Chemistry · 2022 · 84 citations · Full text

Small-molecule factor D inhibitors targeting the alternative complement pathway

Jürgen Maibaum, Sha-Mei Liao, Anna Vulpetti et al. · Nature Chemical Biology · 2016 · 74 citations · Full text

, , +9

Diastereoselective and Enantioselective Intramolecular Amino−Zinc−Enolate Carbometalation Reactions. A New Polysubstituted Pyrrolidines Synthesis

Edwige Lorthiois, Ilane Marek, J. F. NORMANT · The Journal of Organic Chemistry · 1998 · 68 citations

, , +10

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