Marc Gerspacher

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Andreas Weiss, Edwige Lorthiois, Louise Barys et al. · Cancer Discovery · 2022 · 130 citations · Full text

Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805

Fabienne Baffert, Catherine H. Régnier, Alain De Pover et al. · Molecular Cancer Therapeutics · 2010 · 119 citations

Pharmacotherapy, Excellent Selectivity, Pharmaceutical Chemistry +20

JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS^G12C for the Treatment of Solid Tumors

Edwige Lorthiois, Marc Gerspacher, Kim S. Beyer et al. · Journal of Medicinal Chemistry · 2022 · 84 citations · Full text

2-Amino-2-deoxyhexoses as chiral educts for hydroxylated indolizidines. Synthesis of (+)-castanospermine and (+)-6-epicastanospermine

Marc Gerspacher, Henry Rapoport · The Journal of Organic Chemistry · 1991 · 81 citations

Bioorganic Chemistry, Engineering, Natural Sciences +13

1-Alkyl-4-phenyl-6-alkoxy-1<i>H</i>-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists

Leo Widler, Eva Altmann, René Beerli et al. · Journal of Medicinal Chemistry · 2010 · 42 citations · Full text

Parathyroid Disease, Stimulate Pth Release, Pharmacotherapy +17