Concepedia
Bioorganic & Medicinal Chemistry Letters · 2015 · 33 citations · 27 references
Open access
Sleep DisordersSleepSleep MedicineMolecular PharmacologySleep DisorderMedicinePhysiologyNeuropharmacologyOrexin ReceptorInsomniaPharmacologyDrug Discovery
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The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
Luı́s de Lecea, Thomas S. Kilduff, Christelle Peyron et al. · Proceedings of the National Academy of Sciences · 1998 · 3.8K citations
Hypothalamic Circuits, Hypothalamus-specific Mrna, Gastrointestinal Peptide Hormone +17
Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs
J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada et al. · Pharmaceutical Research · 1999 · 792 citations
Promotion of sleep by targeting the orexin system in rats, dogs and humans
Catherine Brisbare‐Roch, Jasper Dingemanse, Ralf Koberstein et al. · Nature Medicine · 2007 · 564 citations
Animal Physiology, Sleep Disorders, Sleep +15
In Vitro P-glycoprotein Assays to Predict the in Vivo Interactions of P-glycoprotein with Drugs in the Central Nervous System
Bo Feng, Jessica B. Mills, Ralph E. Davidson et al. · Drug Metabolism and Disposition · 2007 · 433 citations
Synthetic Applications of Dealkoxycarbonylations of Malonate Esters, β-Keto Esters, α-Cyano Esters and Related Compounds in Dipolar Aprotic Media - Part I
A. Paul Krapcho · Synthesis · 1982 · 383 citations
Malonate Esters, Engineering, Dipolar Aprotic Media +6