Jodi T. Williams

Synthesis of 3,4-Disubstituted Piperidines by Carbonyl Ene and Prins Cyclizations:  A Switch in Diastereoselectivity between Lewis and Brønsted Acid Catalysts

Jodi T. Williams, P.S. Bahia, J. S. Snaith · Organic Letters · 2002 · 52 citations

Chemical Engineering, Engineering, 3,4-Disubstituted Piperidines +11

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders

Christoph Boss, John Gatfield, Christine Brotschi et al. · ChemMedChem · 2020 · 47 citations

Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT‐462206: a Potent, Brain‐Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist

Christoph Boss, Catherine Roch‐Brisbare, Michel A. Steiner et al. · ChemMedChem · 2014 · 40 citations

Structure–activity Relationship, Receptor Antagonist, Pharmacotherapy +24

Synthesis of 3,4-Disubstituted Piperidines by Carbonyl Ene and Prins Cyclizations:  Switching between Kinetic and Thermodynamic Control with Brønsted and Lewis Acid Catalysts

Jodi T. Williams, P.S. Bahia, Benson M. Kariuki et al. · The Journal of Organic Chemistry · 2006 · 35 citations

Chemical Engineering, Lewis Acid Catalysts, Engineering +12

Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2

Thierry Sifferlen, Amandine Boller, Audrey Chardonneau et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 33 citations · Full text

Sleep Disorders, Sleep, Sleep Medicine +9