Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

Mutational landscape and significance across 12 major cancer types

Cyriac Kandoth, Michael D. McLellan, Fabio Vandin et al. · Nature · 2013 · 4.4K citations · Full text

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead et al. · Proceedings of the National Academy of Sciences · 2010 · 4.4K citations · Full text

Histone Modifications, Epigenetic Change, Genetics +20

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Warren A. Whyte, David A. Orlando, Denes Hnisz et al. · Cell · 2013 · 4.2K citations · Full text

Transcriptional Regulation, Developmental Biology, Cell Regulation +9

Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud et al. · Nature · 2010 · 4.2K citations · Full text

Bet Bromodomains, Genetics, Pathogenesis +3

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Nathaniel D. Heintzman, Rhona Stuart, Gary C. Hon et al. · Nature Genetics · 2007 · 3.4K citations

Histone Modifications, Chromatin, Transcriptional Regulation +14