Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Warren A. Whyte, David A. Orlando, Denes Hnisz, +6

Cell

Transcriptional RegulationDevelopmental BiologyCell RegulationTranscription RegulationGene Regulation +7

Super-Enhancers in the Control of Cell Identity and Disease

Denes Hnisz, Brian J. Abraham, Tong Ihn Lee, +5

Cell

Cell RegulationAutoimmunityCell IdentityMedicineCell Biology +2

Coactivator condensation at super-enhancers links phase separation and gene control

Benjamin R. Sabari, Alessandra Dall’Agnese, Ann Boija, +20

Science

EngineeringCoactivator IdrsMolecular BiologyGene Regulatory NetworkProtein Phase Separation +15

Activation of proto-oncogenes by disruption of chromosome neighborhoods

Denes Hnisz, Abraham S. Weintraub, Daniel S. Day, +14

Science

ChromatinGene FusionFocal AmplificationTumor HeterogeneityMixed-phenotype Acute Leukemia +8

YY1 Is a Structural Regulator of Enhancer-Promoter Loops

Abraham S. Weintraub, Charles H. Li, Alicia V. Zamudio, +13

Cell

Transcriptional RegulationGeneticsGene RegulationEnhancer-promoter LoopsMolecular Genetics +5

Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

Jill M. Dowen, Zi Peng Fan, Denes Hnisz, +8

Cell

ChromatinMammalian ChromosomesGeneticsGenomic MechanismChromosome Biology +7

Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

Denes Hnisz, Jurian Schuijers, Charles Y. Lin, +5

Molecular Cell

Transcriptional RegulationFunctional GenomicsDevelopmental BiologySignaling PathwayMedicine +6

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene

X. Shawn Liu, Hao Wu, Marine Krzisch, +12

Cell

Fragile X PremutationChromatinFmr1 GeneMolecular NeuroscienceGenetic Disorder +10

3D Chromosome Regulatory Landscape of Human Pluripotent Cells

Ji Xiong, Daniel Benjamin Dadon, Benjamin E. Powell, +10

Cell stem cell

ChromatinHuman CellInduced Pluripotent Stem CellChromosome Regulatory LandscapeMedicine +2

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

Victoria Clark, Akdes Serin Harmancı, Hanwen Bai, +24

Nature Genetics

Somatic VariantMendelian DisorderRecurrent Somatic MutationsGeneticsMolecular Genetics +4