BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

Georg Winter, Andreas Mayer, Dennis L. Buckley, +19

Molecular Cell

Transcriptional RegulationCell RegulationGeneticsGene RegulationCdk9 Recruitment +5

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

Maria Kleppe, Richard P. Koche, Lihua Zou, +21

Cancer Cell

Hematological MalignancyOncogenic ActivationMalignant Blood DisorderImmunologyMyeloproliferative Neoplasms +8

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

Mira Jeong, Hyun Jung Park, Hamza Celik, +10

Cell Reports

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

Rhamy Zeid, Matthew A. Lawlor, Evon Poon, +16

Nature Genetics

Cell RegulationMycn-dependent Transcriptional AmplificationMedicineCell BiologyTumor Biology

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

Lara Gechijian, Dennis L. Buckley, Matthew A. Lawlor, +14

Nature Chemical Biology

Vhl LigandsMedicinal ChemistryBiochemistryNatural SciencesMolecular Biology +2

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

Shaokun Shu, Hua‐Jun Wu, Jennifer Y. Ge, +36

Molecular Cell

Breast OncologyMedicineResistance InteractionsBreast CancerAnti-cancer Agent +7

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

David P. Labbé, Giorgia Zadra, Meng Yang, +31

Nature Communications

Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

Matthew T. Buckley, Eric Sun, Benson M. George, +9

Nature Aging

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

Aaron D. Viny, Christopher J. Ott, Barbara Spitzer, +14

The Journal of Experimental Medicine

Dose-dependent RoleMixed-phenotype Acute LeukemiaImmunologyPathologySmc3 Deletion +19

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer

Haikuo Zhang, Jun Qi, Jaime M. Reyes, +28

Cancer Discovery