Super-Enhancer Regulation is a transcriptional control mechanism that belongs to the class of enhancer-mediated gene regulatory processes, distinguished by its dependence on large clusters of enhancers with exceptionally high transcription factor density and coactivator recruitment, which collectively drive robust, cell-identity-defining gene expression programs through phase-separated condensates and chromatin looping interactions.
271
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32.4K
Citations
2.8K
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736
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Publications per year
2017–2026
231
Publications
271
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Warren A. Whyte, David A. Orlando, Denes Hnisz et al. · Cell · 2013 · 4.3K citations · Full text
Super-Enhancers in the Control of Cell Identity and Disease
Denes Hnisz, Brian J. Abraham, Tong Ihn Lee et al. · Cell · 2013 · 3.9K citations · Full text
Coactivator condensation at super-enhancers links phase separation and gene control
Benjamin R. Sabari, Alessandra Dall’Agnese, Ann Boija et al. · Science · 2018 · 2.7K citations
An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
Marc R. Mansour, Brian J. Abraham, Lars Anders et al. · Science · 2014 · 818 citations · Full text
1–5 of 271
Authors
2.8K
- RARichard A. Young
Whitehead Institute for Biomedical Research, United States
12 publications · 5.8K citations
11
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- CY
8
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- BJBrian J. Abraham
Whitehead Institute for Biomedical Research, United States
8 publications · 12.8K citations
8
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- JE
7
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- TITong Ihn Lee
Whitehead Institute for Biomedical Research, United States
7 publications · 12K citations
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Institutions
736
Sun Yat-sen University
Guangzhou, China
21 h-index
175 publications
10.4K citations
Dana-Farber Cancer Institute
Boston, United States
21 h-index
86 publications
32.2K citations
Harvard University
Cambridge, United States
19 h-index
112 publications
24.1K citations
National Institutes of Health
Bethesda, United States
18 h-index
90 publications
12.5K citations
Massachusetts Institute of Technology
Cambridge, United States
14 h-index
39 publications
49K citations
Whitehead Institute for Biomedical Research
Cambridge, United States
13 h-index
71 publications
126.1K citations
National Cancer Institute
Bethesda, United States
11 h-index
40 publications
3.3K citations
Howard Hughes Medical Institute
Chevy Chase, United States
11 h-index
29 publications
5K citations
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- Nature Communications
38 publications · 3.2K citations
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- Nucleic Acids Research
23 publications · 1.8K citations
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- Cell Reports
17 publications · 1.5K citations
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- Cell Death and Disease
8 publications · 233 citations
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- PLoS Genetics
6 publications · 269 citations
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