Concepedia

Epigenetic Deregulation

Epigenetic Deregulation is a pathological alteration in gene expression patterns resulting from aberrant epigenetic modifications—such as DNA methylation, histone modification, or non-coding RNA dysregulation—that disrupt normal cellular functions without changes to the underlying DNA sequence, particularly implicated in the development and progression of endocrine tumors.

569

Publications

42.9K

Citations

4.8K

Authors

1.3K

Institutions

Publications per year

2017–2026

203

Parents

Publications

569

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

Amir Eden, François Gaudet, Alpana Waghmare et al. · Science · 2003 · 1.4K citations

, , +15

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

Sooryanarayana Varambally, Qi Cao, Ram S. Mani et al. · Science · 2008 · 1.1K citations · Full text

, , +17

Suppression of intestinal neoplasia by DNA hypomethylation

Peter W. Laird, Laurie Jackson‐Grusby, Amin Fazeli et al. · Cell · 1995 · 714 citations · Full text

, , +14

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

Laurie Jackson‐Grusby, Caroline Beard, Richard Possemato et al. · Nature Genetics · 2001 · 699 citations

, , +16

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

Jun Hyung Park, Doris A. Stoffers, Robert D. Nicholls et al. · Journal of Clinical Investigation · 2008 · 634 citations · Full text

, , +16

1–5 of 569

Authors

4.8K

  1. ME
    Manel Esteller

    Institut d'Investigació Biomédica de Bellvitge, Spain

    10 publications · 681 citations

    10

    h-index

  2. CJ
    Cármen Jerónimo

    Instituto Português de Oncologia Francisco Gentil, Portugal

    7 publications · 371 citations

    7

    h-index

  3. RH
    Rui Henrique

    Instituto Português de Oncologia Francisco Gentil, Portugal

    7 publications · 371 citations

    7

    h-index

  4. SJ
    Susan J. Clark

    Garvan Institute of Medical Research, Australia

    6 publications · 503 citations

    6

    h-index

  5. CS
    Clare Stirzaker

    Garvan Institute of Medical Research, Australia

    6 publications · 503 citations

    6

    h-index

1–5 of 4.8K

Institutions

1.3K

  1. Inserm

    Paris, France

    20 h-index

    148 publications

    10.7K citations

  2. Heidelberg University

    Heidelberg, Germany

    13 h-index

    98 publications

    6.2K citations

  3. Harvard University

    Cambridge, United States

    13 h-index

    71 publications

    5.1K citations

  4. Institut d'Investigació Biomédica de Bellvitge

    Barcelona, Spain

    12 h-index

    82 publications

    8.3K citations

  5. German Cancer Research Center

    Heidelberg, Germany

    12 h-index

    83 publications

    5.2K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    65 publications

    3.6K citations

  7. University of Pennsylvania

    Philadelphia, United States

    11 h-index

    53 publications

    5.9K citations

  8. Institució Catalana de Recerca i Estudis Avançats

    Barcelona, Spain

    10 h-index

    13 publications

    1.3K citations

1–8 of 1.3K

Venues

  1. Oncogene

    21 publications · 2.1K citations

    21

    h-index

  2. PLoS ONE

    18 publications · 1.3K citations

    16

    h-index

  3. Cancer Research

    15 publications · 1.6K citations

    15

    h-index

  4. PubMed

    Repository · 16 publications · 570 citations

    13

    h-index

  5. Oncotarget

    13 publications · 595 citations

    12

    h-index

1–5