Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

Abstract

Human tumors often display changes in DNA methylation, including both genome-wide hypomethylation and site-specific hypermethylation ( [1][1], [2][2] ). In mice, DNA hypomethylation is sufficient to induce T cell lymphomas with consistent gain of chromosome 15 ( [3][3] ), indicating that genome-wide