Concepedia

Genome Instability

Genome Instability is a pathological condition characterized by an increased tendency for alterations in the genome, such as mutations, chromosomal rearrangements, or aneuploidy, resulting from defects in DNA repair, cell cycle control, or chromatin regulation mechanisms.

2.1K

Publications

202.5K

Citations

11.1K

Authors

2.2K

Institutions

Publications per year

2017–2026

395

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Children

Publications

2.1K

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

C. Richard Boland, Stephen N. Thibodeau, Stanley R. Hamilton et al. · PubMed · 1998 · 4.1K citations

, , +17

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Christopher M. Counter, Ariel A. Avilion, Catherine LeFeuvre et al. · The EMBO Journal · 1992 · 2.1K citations · Full text

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Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

Ying‐Hui Fu, Derek P.A. Kuhl, Antonio Pizzuti et al. · Cell · 1991 · 2.1K citations

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Genetic instability in colorectal cancers

Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein · Nature · 1997 · 2K citations

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Vassilis G. Gorgoulis, Leandros-Vassilios Vassiliou, Panagiotis Karakaidos et al. · Nature · 2005 · 2K citations

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1–5 of 2.1K

Authors

11.1K

  1. TD
    Thomas D. Petes

    University of North Carolina at Chapel Hill, United States

    22 publications · 2.2K citations

    21

    h-index

  2. ID
    Ian D. Hickson

    John Radcliffe Hospital, United Kingdom

    17 publications · 2.6K citations

    17

    h-index

  3. AA
    Andrés Aguilera

    Universidad de Sevilla, Spain

    17 publications · 2.2K citations

    17

    h-index

  4. BV
    Bert Vogelstein

    Johns Hopkins University, United States

    16 publications · 7.3K citations

    16

    h-index

  5. SM
    Sergei M. Mirkin

    Tufts University, United States

    15 publications · 845 citations

    15

    h-index

1–5 of 11.1K

Institutions

2.2K

  1. Harvard University

    Cambridge, United States

    48 h-index

    282 publications

    96.7K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    44 h-index

    187 publications

    97.3K citations

  3. National Institutes of Health

    Bethesda, United States

    40 h-index

    244 publications

    42.8K citations

  4. Inserm

    Paris, France

    39 h-index

    270 publications

    26.8K citations

  5. University of Toronto

    Toronto, Canada

    38 h-index

    159 publications

    25.2K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    36 h-index

    256 publications

    21.6K citations

  7. Johns Hopkins University

    Baltimore, United States

    33 h-index

    172 publications

    58K citations

  8. Cornell University

    Ithaca, United States

    30 h-index

    107 publications

    31.8K citations

1–8 of 2.2K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 91 publications · 11.9K citations

    58

    h-index

  2. PubMed

    Repository · 122 publications · 15K citations

    57

    h-index

  3. Molecular and Cellular Biology

    MCB · 61 publications · 6.7K citations

    48

    h-index

  4. Human Molecular Genetics

    53 publications · 5.2K citations

    40

    h-index

  5. Oncogene

    53 publications · 4.2K citations

    40

    h-index

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