Concepedia

Substituent Optimization

Substituent Optimization is a chemical design strategy that systematically modifies molecular substituents to enhance metabolic stability by improving enzymatic resistance without compromising pharmacological activity.

14

Publications

740

Citations

119

Authors

13

Institutions

Publications per year

2017–2026

3

Parents

Publications

14

Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs

Armin Buschauer · Journal of Medicinal Chemistry · 1989 · 112 citations · Full text

, , +12

Evaluating the Differences in Cycloalkyl Ether Metabolism Using the Design Parameter “Lipophilic Metabolism Efficiency” (LipMetE) and a Matched Molecular Pairs Analysis

Antonia F. Stepan, Gregory W. Kauffman, Christopher Keefer et al. · Journal of Medicinal Chemistry · 2013 · 92 citations

, , +15

Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2-<i>d</i>]pyrimidines and Pyrimido[5,4-<i>b</i>]- and -[4,5-<i>b</i>]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase

H. D. Hollis Showalter, Alexander J. Bridges, Hairong Zhou et al. · Journal of Medicinal Chemistry · 1999 · 88 citations · Full text

, , +16

Discovery of Pyrazine-Carboxamide-Diphenyl-Ethers as Novel Succinate Dehydrogenase Inhibitors via Fragment Recombination

Hua Li, Mengqi Gao, Yan Chen et al. · Journal of Agricultural and Food Chemistry · 2020 · 74 citations

, , +16

Optimization of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase

F. Scott Kimball, F. Anthony Romero, Cyrine Ezzili et al. · Journal of Medicinal Chemistry · 2008 · 61 citations · Full text

, , +16

1–5 of 14

Authors

119

  1. PR
    Paul R. O. Whittamore

    AstraZeneca (United Kingdom), United Kingdom

    2 publications · 56 citations

    2

    h-index

  2. JG
    John G. Swales

    AstraZeneca (United Kingdom), United Kingdom

    2 publications · 56 citations

    2

    h-index

  3. NS
    Nidhal Selmi

    AstraZeneca (Sweden), Sweden

    2 publications · 56 citations

    2

    h-index

  4. EK
    Elaine Kilgour

    AstraZeneca (United Kingdom), United Kingdom

    2 publications · 56 citations

    2

    h-index

  5. MJ
    Martin J. Packer

    AstraZeneca (United Kingdom), United Kingdom

    2 publications · 56 citations

    2

    h-index

1–5 of 119

Institutions

13

  1. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    2 h-index

    26 publications

    728 citations

  2. Scripps Research Institute

    San Diego, United States

    2 h-index

    15 publications

    796 citations

  3. Central China Normal University

    Wuhan, China

    1 h-index

    6 publications

    444 citations

  4. University of Toledo

    Toledo, United States

    1 h-index

    8 publications

    120 citations

  5. Ministry of Education

    Wellington, New Zealand

    1 h-index

    3 publications

    69 citations

  6. Pfizer (United States)

    New York, United States

    1 h-index

    5 publications

    460 citations

  7. Nankai University

    Tianjin, China

    1 h-index

    8 publications

    288 citations

  8. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    1 h-index

    22 publications

    1.1K citations

1–8 of 13

Venues

  1. Journal of Medicinal Chemistry

    6 publications · 458 citations

    6

    h-index

  2. Journal of Agricultural and Food Chemistry

    2 publications · 110 citations

    2

    h-index

  3. Journal of the American Chemical Society

    JACS · 2 publications · 74 citations

    2

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    1 publications · 49 citations

    1

    h-index

  5. MedChemComm

    1 publications · 11 citations

    1

    h-index

1–5