Paul R. O. Whittamore

Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3<i>S</i>)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)

James S. Scott, Suzanne S. Bowker, Joanne deSchoolmeester et al. · Journal of Medicinal Chemistry · 2012 · 62 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4-[4-(2-Adamantylcarbamoyl)-5-<i>tert</i>-butyl-pyrazol-1-yl]benzoic Acid (AZD8329)

James S. Scott, Joanne deSchoolmeester, Elaine Kilgour et al. · Journal of Medicinal Chemistry · 2012 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors

Alan M. Birch, Peter W. Kenny, Iain Simpson et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 42 citations

Life Sciences, Biochemistry, Molecular Biology +13

Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors

Alan M. Birch, Peter W. Kenny, Nikos G. Oikonomakos et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

A Novel Approach to Dual-Acting Thromboxane Receptor Antagonist/Synthase Inhibitors Based on the Link of 1,3-Dioxane-Thromboxane Receptor Antagonists and -Thromboxane Synthase Inhibitors

Norman Ackerley, Andrew G. Brewster, George R. Brown et al. · Journal of Medicinal Chemistry · 1995 · 29 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8