Joanne deSchoolmeester

Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3<i>S</i>)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)

James S. Scott, Suzanne S. Bowker, Joanne deSchoolmeester et al. · Journal of Medicinal Chemistry · 2012 · 59 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Metabolic Syndrome +15

Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4-[4-(2-Adamantylcarbamoyl)-5-<i>tert</i>-butyl-pyrazol-1-yl]benzoic Acid (AZD8329)

James S. Scott, Joanne deSchoolmeester, Elaine Kilgour et al. · Journal of Medicinal Chemistry · 2012 · 42 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Metabolic Syndrome +14

11-Dehydrocorticosterone Causes Metabolic Syndrome, Which Is Prevented when 11β-HSD1 Is Knocked Out in Livers of Male Mice

Erika Harno, Elizabeth C. Cottrell, Brian Keevil et al. · Endocrinology · 2013 · 35 citations · Full text

Metabolic Disorder, Glucocorticoid, Insulin Signaling +22

11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms

Erika Harno, Elizabeth C. Cottrell, Alice Yu et al. · Endocrinology · 2013 · 27 citations · Full text

Metabolic Disorder, Genetics, Caloric Restriction +24

Optimization of Brain Penetrant 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet-Induced Obese Mice

Frederick W. Goldberg, Alexander G. Dossetter, James S. Scott et al. · Journal of Medicinal Chemistry · 2014 · 24 citations · Full text

Metabolic Disorder, Vivo Testing, Insulin Signaling +22