Concepedia

Somatic Hypermutation

Somatic Hypermutation is a genetically programmed, enzyme-mediated process of localized, high-frequency point mutations occurring in the variable regions of immunoglobulin genes within activated B cells, which serves to increase antibody affinity during adaptive immune responses.

1.7K

Publications

176.8K

Citations

9K

Authors

1.8K

Institutions

Publications per year

2017–2026

223

Variants

Shm

Parents

Children

Publications

1.7K

Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith et al. · Nature · 2007 · 3.1K citations · Full text

, , +14

Somatic mutations affect key pathways in lung adenocarcinoma

Li Ding, Gad Getz, David A. Wheeler et al. · Nature · 2008 · 2.7K citations · Full text

, , +16

Absolute quantification of somatic DNA alterations in human cancer

Scott L. Carter, Kristian Cibulskis, Elena Helman et al. · Nature Biotechnology · 2012 · 2.2K citations · Full text

, , +16

Somatic <i>CALR</i> Mutations in Myeloproliferative Neoplasms with Nonmutated <i>JAK2</i>

Jyoti Nangalia, Charles Massie, E. Joanna Baxter et al. · New England Journal of Medicine · 2013 · 1.7K citations · Full text

, , +15

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Ryan D. Morin, Nathalie A. Johnson, Tesa Severson et al. · Nature Genetics · 2010 · 1.6K citations · Full text

, , +16

1–5 of 1.7K

Authors

9K

  1. KR
    Klaus Rajewsky

    University of Cologne, Germany

    38 publications · 6.4K citations

    32

    h-index

  2. MS
    Michael S. Neuberger

    MRC Laboratory of Molecular Biology, United Kingdom

    31 publications · 5.3K citations

    29

    h-index

  3. MD
    Matthew D. Scharff

    Albert Einstein College of Medicine, United States

    40 publications · 2.8K citations

    28

    h-index

  4. TH
    Tasuku Honjo

    Kyoto University, Japan

    26 publications · 3K citations

    24

    h-index

  5. PJ
    Patricia J. Gearhart

    National Institute on Aging, United States

    25 publications · 2.3K citations

    22

    h-index

1–5 of 9K

Institutions

1.8K

  1. National Institutes of Health

    Bethesda, United States

    47 h-index

    347 publications

    41.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    46 h-index

    158 publications

    35.3K citations

  3. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    46 h-index

    187 publications

    29.5K citations

  4. Harvard University

    Cambridge, United States

    43 h-index

    339 publications

    111.3K citations

  5. Yale University

    New Haven, United States

    37 h-index

    231 publications

    36K citations

  6. University of Cologne

    Cologne, Germany

    36 h-index

    180 publications

    29.8K citations

  7. Albert Einstein College of Medicine

    Bronx, United States

    36 h-index

    222 publications

    18.8K citations

  8. Medical Research Council

    London, United Kingdom

    36 h-index

    131 publications

    24.9K citations

1–8 of 1.8K

Venues

  1. The Journal of Experimental Medicine

    123 publications · 16.4K citations

    71

    h-index

  2. Blood

    103 publications · 13.6K citations

    68

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 102 publications · 11.9K citations

    64

    h-index

  4. The Journal of Immunology

    JI · 187 publications · 11.5K citations

    60

    h-index

  5. Nature

    54 publications · 27.8K citations

    49

    h-index

1–5