Concepedia

Coldspot Mutations

Coldspot Mutations is a mutational pattern in immunoglobulin genes characterized by genomic regions exhibiting significantly lower somatic mutation frequencies compared to the surrounding sequence, thereby distinguishing them as zones of reduced hypermutation activity within the broader process of somatic hypermutation.

5

Publications

241

Citations

18

Authors

15

Institutions

Publications per year

2017–2026

2

Parents

Publications

5

A Phylogenetic Codon Substitution Model for Antibody Lineages

Kenneth B. Hoehn, Gerton Lunter, Oliver G. Pybus · Genetics · 2017 · 80 citations · Full text

, , +15

Predicted and inferred waiting times for key mutations in the germinal centre reaction: Evidence for stochasticity in selection

Michael D. Radmacher, Garnett Kelsoe, Thomas B. Kepler · Immunology and Cell Biology · 1998 · 66 citations · Full text

, , +16

Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease

Navaneethakrishnan Krishnamoorthy, Khalid A. Fakhro · IUBMB Life · 2021 · 43 citations · Full text

, , +16

Increased Rate of Deleterious Variants in Long Runs of Homozygosity of an Inbred Population from Qatar

Massimo Mezzavilla, Diego Vozzi, Ramin Badii et al. · Human Heredity · 2015 · 32 citations

, , +17

Single Nucleotide Positions Have Proximal and Distal Influence on UV Mutation Hotspots and Coldspots

Dan D. Levy, Ashalla D. Magee, Michael M. Seidman · Journal of Molecular Biology · 1996 · 20 citations

, , +14

1–5 of 5

Authors

18

  1. DD
    Dan D. Levy

    Center for Food Safety and Applied Nutrition, United States

    1 publications · 20 citations

    1

    h-index

  2. KB
    Kenneth B. Hoehn

    Yale University, United States

    1 publications · 80 citations

    1

    h-index

  3. MM
    Massimo Mezzavilla

    IRCCS Materno Infantile Burlo Garofolo, Italy

    1 publications · 32 citations

    1

    h-index

  4. MD
    Michael D. Radmacher

    The Ohio State University, United States

    1 publications · 66 citations

    1

    h-index

  5. KA
    Khalid A. Fakhro

    Weill Cornell Medical College in Qatar, Qatar

    1 publications · 43 citations

    1

    h-index

1–5 of 18

Institutions

15

  1. National Institutes of Health

    Bethesda, United States

    1 h-index

    1 publications

    20 citations

  2. University of Oxford

    Oxford, United Kingdom

    1 h-index

    3 publications

    240 citations

  3. Centre for Human Genetics

    Oxford, United Kingdom

    1 h-index

    2 publications

    160 citations

  4. Sidra Medical and Research Center

    Doha, Qatar

    1 h-index

    2 publications

    86 citations

  5. Laboratory of Molecular Genetics

    Poznań, Poland

    1 h-index

    2 publications

    64 citations

  6. IRCCS Materno Infantile Burlo Garofolo

    Trieste, Italy

    1 h-index

    3 publications

    96 citations

  7. Qatar Airways (Qatar)

    Doha, Qatar

    1 h-index

    2 publications

    86 citations

  8. Genesis Laboratories

    Wellington, United States

    1 h-index

    2 publications

    40 citations

1–8 of 15

Venues

  1. IUBMB Life

    1 publications · 43 citations

    1

    h-index

  2. Immunology and Cell Biology

    1 publications · 66 citations

    1

    h-index

  3. Genetics

    1 publications · 80 citations

    1

    h-index

  4. Human Heredity

    1 publications · 32 citations

    1

    h-index

  5. Journal of Molecular Biology

    JMB · 1 publications · 20 citations

    1

    h-index

1–5