Concepedia

Proteasome Activity Profiling

Proteasome Activity Profiling is an activity-based protein profiling method that selectively monitors the functional state of proteasomes by covalently labeling their active sites with chemical probes to distinguish catalytically active forms from inactive or inhibited complexes within the cellular proteome.

147

Publications

7.3K

Citations

931

Authors

326

Institutions

Publications per year

2017–2026

36

Parents

Publications

147

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

Mikael Altun, Holger Kramer, Lianne I. Willems et al. · Chemistry & Biology · 2011 · 403 citations

, , +11

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

Jeffrey N. Keller, Fengfa Huang, William R. Markesbery · Neuroscience · 2000 · 297 citations

, , +14

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

Celia R. Berkers, Martijn Verdoes, Eben I. Lichtman et al. · Nature Methods · 2005 · 266 citations

, , +12

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

Alexander Arlt, Iris Bauer, Clemens Schafmayer et al. · Oncogene · 2009 · 250 citations

, , +13

Activation of the Cardiac Proteasome During Pressure Overload Promotes Ventricular Hypertrophy

Christophe Depré, Qian Wang, Lin Yan et al. · Circulation · 2006 · 216 citations

, , +17

1–5 of 147

Authors

931

  1. HS
    Herman S. Overkleeft

    Leiden University, Netherlands

    16 publications · 872 citations

    14

    h-index

  2. BI
    Bogdan I. Florea

    Leiden University, Netherlands

    9 publications · 416 citations

    9

    h-index

  3. HO
    Huib Ovaa

    The Netherlands Cancer Institute, Netherlands

    9 publications · 775 citations

    9

    h-index

  4. MV
    Martijn Verdoes

    Radboud University Nijmegen, Netherlands

    8 publications · 638 citations

    8

    h-index

  5. RA
    Renier A. L. van der Hoorn

    Max Planck Institute for Plant Breeding Research, Germany

    6 publications · 197 citations

    6

    h-index

1–5 of 931

Institutions

326

  1. Leiden University

    Leiden, The Netherlands

    12 h-index

    67 publications

    4K citations

  2. Harvard University

    Cambridge, United States

    8 h-index

    33 publications

    3.8K citations

  3. Max Planck Institute for Plant Breeding Research

    Cologne, Germany

    6 h-index

    34 publications

    1.6K citations

  4. University of Duisburg-Essen

    Essen, Germany

    6 h-index

    21 publications

    1K citations

  5. The Netherlands Cancer Institute

    Amsterdam, The Netherlands

    6 h-index

    22 publications

    1.8K citations

  6. Netherlands Metabolomics Centre

    Utrecht, The Netherlands

    5 h-index

    31 publications

    2K citations

  7. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    5 h-index

    25 publications

    2.2K citations

  8. Medical University of Białystok

    Bialystok, Poland

    5 h-index

    22 publications

    368 citations

1–8 of 326

Venues

  1. PLoS ONE

    6 publications · 200 citations

    6

    h-index

  2. Angewandte Chemie International Edition

    4 publications · 325 citations

    4

    h-index

  3. Analytical Biochemistry

    4 publications · 164 citations

    4

    h-index

  4. Methods in enzymology on CD-ROM/Methods in enzymology

    Book series · 4 publications · 169 citations

    4

    h-index

  5. Methods in molecular biology

    Book series · 4 publications · 66 citations

    4

    h-index

1–5