Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

Teru Hideshima, Paul G. Richardson, D Chauhan et al. · PubMed · 2001 · 1.5K citations

Proteasome Inhibitors, Human Mm Cells, Apoptosis +19

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

Julian Adams, Vito J. Palombella, Edward A. Sausville et al. · PubMed · 1999 · 1.5K citations

Proteasome Inhibitors, Effective Antitumor Agents, Proteasome +21

Activity-based protein profiling: The serine hydrolases

Yongsheng Liu, Matthew P. Patricelli, Benjamin F. Cravatt · Proceedings of the National Academy of Sciences · 1999 · 1.1K citations · Full text

Protein Chemistry, Protein Function, Biochemistry +14

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

Nico P. Dantuma, Kristina Lindsten, Rickard Glas et al. · Nature Biotechnology · 2000 · 610 citations

Living Cells, Protein Function, Biochemistry +12

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

Doron C. Greenbaum, Katalin F. Medzihradszky, Alma L. Burlingame et al. · Chemistry & Biology · 2000 · 582 citations · Full text

Cellular Enzymology, Biochemistry, Natural Sciences +10