Concepedia

Activity-based Probe Design

Activity-Based Probe Design is a chemical biology strategy that employs reactive small molecules to covalently modify active enzymes in complex biological systems, enabling the selective profiling of enzymatic activity through mechanism-based targeting of catalytically competent residues.

178

Publications

8.2K

Citations

1K

Authors

306

Institutions

Publications per year

2017–2026

72

Parents

Publications

178

Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events

Shirin Arastu‐Kapur, Janet L. Anderl, Marianne Kraus et al. · Clinical Cancer Research · 2011 · 409 citations

, , +15

Profiling Serine Hydrolase Activities in Complex Proteomes

Dana Kidd, Yongsheng Liu, Benjamin F. Cravatt · Biochemistry · 2001 · 366 citations

, , +16

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

Celia R. Berkers, Martijn Verdoes, Eben I. Lichtman et al. · Nature Methods · 2005 · 266 citations

, , +12

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Haidong Li, Heejeong Kim, Jingjing Han et al. · Aggregate · 2021 · 189 citations · Full text

, , +17

An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells

Kaizhi Gu, Wanshan Qiu, Zhiqian Guo et al. · Chemical Science · 2018 · 182 citations · Full text

, , +17

1–5 of 178

Authors

1K

  1. MB
    Matthew Bogyo

    Stanford University, United States

    14 publications · 652 citations

    13

    h-index

  2. HS
    Herman S. Overkleeft

    Leiden University, Netherlands

    12 publications · 398 citations

    12

    h-index

  3. SH
    Steven H. L. Verhelst

    KU Leuven, Belgium

    9 publications · 266 citations

    9

    h-index

  4. BF
    Benjamin F. Cravatt

    Scripps Research Institute, United States

    8 publications · 801 citations

    8

    h-index

  5. HO
    Huib Ovaa

    The Netherlands Cancer Institute, Netherlands

    8 publications · 734 citations

    8

    h-index

1–5 of 1K

Institutions

306

  1. Leiden University

    Leiden, The Netherlands

    13 h-index

    87 publications

    3.3K citations

  2. Scripps Research Institute

    San Diego, United States

    13 h-index

    44 publications

    3.2K citations

  3. Stanford University

    Stanford, United States

    12 h-index

    54 publications

    2.9K citations

  4. Technical University of Munich

    Munich, Germany

    9 h-index

    34 publications

    1.2K citations

  5. National University of Singapore

    Singapore, Singapore

    7 h-index

    28 publications

    1.1K citations

  6. Center for Integrated Protein Science Munich

    Munich, Germany

    7 h-index

    18 publications

    730 citations

  7. Leiden University Medical Center

    Leiden, The Netherlands

    7 h-index

    31 publications

    1.8K citations

  8. University of Bonn

    Bonn, Germany

    7 h-index

    34 publications

    869 citations

1–8 of 306

Venues

  1. Journal of the American Chemical Society

    JACS · 20 publications · 1.3K citations

    20

    h-index

  2. Angewandte Chemie International Edition

    15 publications · 708 citations

    15

    h-index

  3. Chemical Communications

    ChemComm · 10 publications · 350 citations

    10

    h-index

  4. ACS Chemical Biology

    10 publications · 346 citations

    10

    h-index

  5. ChemBioChem

    9 publications · 335 citations

    9

    h-index

1–5