Concepedia

Post-translational Modification Optimization

Post-Translational Modification Optimization is a methodological framework in protein expression optimization that systematically enhances the fidelity, efficiency, and functionality of post-translational modifications through targeted modulation of cellular machinery, enzymatic activities, and environmental conditions to achieve desired protein structure and activity.

26

Publications

1.4K

Citations

164

Authors

64

Institutions

Publications per year

2017–2026

11

Parents

Publications

26

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 333 citations

, , +13

Development of an LC-MS/MS peptide mapping protocol for the NISTmAb

Trina Mouchahoir, John E. Schiel · Analytical and Bioanalytical Chemistry · 2018 · 137 citations · Full text

, , +14

PyTMs: a useful PyMOL plugin for modeling common post-translational modifications

Andreas Warnecke, Tatyana Sandalova, Adnane Achour et al. · BMC Bioinformatics · 2014 · 128 citations · Full text

, , +13

A Modular Toolkit for Generating <i>Pichia pastoris</i> Secretion Libraries

Ulrike Obst, Timothy K. Lu, Volker Sieber · ACS Synthetic Biology · 2017 · 115 citations

, , +17

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Brian S. Gerstenberger, John D. Trzupek, C. Tallant et al. · Journal of Medicinal Chemistry · 2016 · 110 citations · Full text

, , +16

1–5 of 26

Authors

164

  1. CL
    Christa L. Feasley

    University of Oklahoma Health Sciences Center, United States

    2 publications · 28 citations

    2

    h-index

  2. FE
    Fred E. Regnier

    Purdue University West Lafayette, United States

    2 publications · 28 citations

    2

    h-index

  3. WS
    Wolfgang Skranc

    DSM (Austria), Austria

    1 publications · 17 citations

    1

    h-index

  4. TK
    Timothy K. Lu

    Massachusetts Institute of Technology, United States

    1 publications · 115 citations

    1

    h-index

  5. SP
    S. Picaud

    University of Oxford, United Kingdom

    1 publications · 110 citations

    1

    h-index

1–5 of 164

Institutions

64

  1. Purdue University West Lafayette

    West Lafayette, United States

    2 h-index

    6 publications

    84 citations

  2. Science for Life Laboratory

    Stockholm, Sweden

    1 h-index

    2 publications

    256 citations

  3. Ghent University

    Ghent, Belgium

    1 h-index

    1 publications

    10 citations

  4. Interactions Arbres-Microorganismes

    Nancy, France

    1 h-index

    3 publications

    72 citations

  5. Biocon (Switzerland)

    Delémont, Switzerland

    1 h-index

    1 publications

    25 citations

  6. Shihezi University

    Shihezi, China

    1 h-index

    1 publications

    27 citations

  7. Shenyang Pharmaceutical University

    Shenyang, China

    1 h-index

    6 publications

    72 citations

  8. Advanced Bioscience Laboratories (United States)

    Rockville, United States

    1 h-index

    2 publications

    274 citations

1–8 of 64

Venues

  1. ACS Synthetic Biology

    2 publications · 142 citations

    2

    h-index

  2. Journal of Medicinal Chemistry

    2 publications · 120 citations

    2

    h-index

  3. Journal of Chromatography A

    2 publications · 28 citations

    2

    h-index

  4. Journal of Biotechnology

    2 publications · 72 citations

    2

    h-index

  5. Journal of Biological Chemistry

    JBC · 2 publications · 104 citations

    2

    h-index

1–5