Brian S. Gerstenberger

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Paul V. Fish, P. Filippakopoulos, Gerwyn Bish et al. · Journal of Medicinal Chemistry · 2012 · 196 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

( <i>R</i> )-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Dalia Baršytė-Lovejoy, Fengling Li, Menno J. Oudhoff et al. · Proceedings of the National Academy of Sciences · 2014 · 188 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +13

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 174 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

Oleg Fedorov, Josefina Castex, C. Tallant et al. · Science Advances · 2015 · 144 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +7

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Brian S. Gerstenberger, John D. Trzupek, C. Tallant et al. · Journal of Medicinal Chemistry · 2016 · 110 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16