John D. Trzupek

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Paul V. Fish, P. Filippakopoulos, Gerwyn Bish et al. · Journal of Medicinal Chemistry · 2012 · 195 citations · Full text

Histone Modifications, Pharmaceutical Science, Drug Target +20

Identification of <i>N</i>-{<i>cis</i>-3-[Methyl(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Michael L. Vazquez, Neelu Kaila, Joseph W. Strohbach et al. · Journal of Medicinal Chemistry · 2018 · 160 citations · Full text

Immunodeficiencies, Janus Kinases, Immunology +22

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

Oleg Fedorov, Josefina Castex, C. Tallant et al. · Science Advances · 2015 · 142 citations · Full text

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 138 citations · Full text

Total Synthesis of Chloropeptin II (Complestatin) and Chloropeptin I

Joie Garfunkle, F. Scott Kimball, John D. Trzupek et al. · Journal of the American Chemical Society · 2009 · 118 citations · Full text