John D. Trzupek - Concepedia

Author

John D. Trzupek

Pfizer (United States)ORCID

Also Known As

J. D. Trzupek, J. Trzupek, John D Trzupek, John D. Trzupek, John Trzupek, Trzupek, J.D., Trzupek, John D.

Publications

1.5K

Citations

H-Index

Concepts

All Affiliations

Pfizer (United States)Scripps Research Institute Columbia University University of Oxford Kettering University

About

John D. Trzupek is an author at Pfizer (United States) specializing in natural sciences, pharmacology, and medicine.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	7	7	528
2	Medicine	6	6	584
3	Biochemistry	6	6	558
4	Engineering	3	3	180
5	Biomolecular Engineering	3	3	180

John D. Trzupek

Publications

1.4K

Citations

H-Index

Page 1

	Year	Citations
Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit Paul V. Fish, P. Filippakopoulos, Gerwyn Bish, Journal of Medicinal Chemistry Histone ModificationsPharmaceutical ScienceDrug TargetBioorganic ChemistryFragment-derived Hit	2012	195
Identification of <i>N</i>-{<i>cis</i>-3-[Methyl(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases Michael L. Vazquez, Neelu Kaila, Joseph W. Strohbach, Journal of Medicinal Chemistry ImmunodeficienciesJanus KinasesImmunologyPharmacotherapyImmunotherapy	2018	160
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance Oleg Fedorov, Josefina Castex, C. Tallant, Science Advances	2015	142
Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design Katherine L. Lee, Catherine M. Ambler, David R. Anderson, Journal of Medicinal Chemistry	2017	138
Total Synthesis of Chloropeptin II (Complestatin) and Chloropeptin I Joie Garfunkle, F. Scott Kimball, John D. Trzupek, Journal of the American Chemical Society	2009	118
Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit Brian S. Gerstenberger, John D. Trzupek, C. Tallant, Journal of Medicinal Chemistry Molecular BiologyChemical BiologyPharmaceutical ChemistryMedicinal ChemistryBioanalysis	2016	107
Total Synthesis of Complestatin: Development of a Pd(0)-Mediated Indole Annulation for Macrocyclization Hiroyuki Shimamura, Steven P. Breazzano, Joie Garfunkle, Journal of the American Chemical Society EngineeringOrganic ChemistryMacrocyclization ClosureChemistryHeterocycle Chemistry	2010	78
Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet−Spengler Reaction: Traceless Transfer of Chirality from <scp>l</scp>-Tryptophan John D. Trzupek, Dongjoo Lee, Brendan M. Crowley, Journal of the American Chemical Society BiosynthesisEngineeringNatural Product SynthesisBiochemistryAlkaloid Phalarine	2010	76
Asymmetric Total Synthesis of (+)- and <i>ent</i>-(−)-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer Mark S. Tichenor, John D. Trzupek, David B. Kastrinsky, Journal of the American Chemical Society	2006	75
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin John D. Trzupek, Joel Gottesfeld, Dale L. Boger Nature Chemical Biology ChromatinNucleosome Core ParticlesBiochemistryNatural SciencesOligonucleotide	2006	61

Page 1