Concepedia

Fc Receptor Binding Engineering

Fc Receptor Binding Engineering is a methodological framework within antibody engineering that specifically involves the rational modification of the fragment crystallizable (Fc) region of immunoglobulins to modulate selective interactions with Fc receptors, thereby enhancing or suppressing downstream immune effector functions.

68

Publications

3.7K

Citations

475

Authors

131

Institutions

Publications per year

2017–2026

16

Parents

Publications

68

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

William F. Dall’Acqua, Peter A. Kiener, Herren Wu · Journal of Biological Chemistry · 2006 · 637 citations · Full text

, , +15

Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences

William F. Dall’ Acqua, Robert M. Woods, E. Sally Ward et al. · The Journal of Immunology · 2002 · 367 citations

, , +13

Monoclonal Antibody Clearance

Amita Datta‐Mannan, Derrick R. Witcher, Ying Tang et al. · Journal of Biological Chemistry · 2006 · 163 citations · Full text

, , +17

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

Yang Chen, Joseph P. Balthasar · The AAPS Journal · 2012 · 103 citations · Full text

, , +17

The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates

Jonathan Zalevsky, Irene Leung, Sher Karki et al. · Blood · 2008 · 101 citations · Full text

, , +17

1–5 of 68

Authors

475

  1. JR
    John R. Desjarlais

    Xencor (United States), United States

    4 publications · 279 citations

    4

    h-index

  2. SK
    Sher Karki

    Xencor (United States), United States

    4 publications · 204 citations

    4

    h-index

  3. SY
    Seung Y. Chu

    Xencor (United States), United States

    4 publications · 279 citations

    4

    h-index

  4. IS
    Inger Sandlie

    University of Oslo, Norway

    3 publications · 135 citations

    3

    h-index

  5. JT
    Jan Terje Andersen

    University of Oslo, Norway

    3 publications · 135 citations

    3

    h-index

1–5 of 475

Institutions

131

  1. Xencor (United States)

    Monrovia, United States

    6 h-index

    50 publications

    3K citations

  2. KTH Royal Institute of Technology

    Stockholm, Sweden

    3 h-index

    7 publications

    259 citations

  3. University of Oslo

    Oslo, Norway

    3 h-index

    4 publications

    218 citations

  4. Aarhus University

    Aarhus, Denmark

    3 h-index

    11 publications

    267 citations

  5. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    3 h-index

    11 publications

    537 citations

  6. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    8 publications

    277 citations

  7. Roche (Switzerland)

    Basel, Switzerland

    2 h-index

    15 publications

    343 citations

  8. UCB Pharma (United Kingdom)

    Slough, United Kingdom

    2 h-index

    14 publications

    376 citations

1–8 of 131

Venues

  1. Molecular Immunology

    8 publications · 338 citations

    8

    h-index

  2. Blood

    5 publications · 268 citations

    5

    h-index

  3. mAbs

    4 publications · 207 citations

    4

    h-index

  4. Journal of Immunological Methods

    4 publications · 141 citations

    4

    h-index

  5. Journal of Biological Chemistry

    JBC · 3 publications · 863 citations

    3

    h-index

1–5