Irene Leung

Enhanced antibody half-life improves in vivo activity

Jonathan Zalevsky, Aaron K. Chamberlain, Holly M. Horton et al. · Nature Biotechnology · 2010 · 644 citations · Full text

Pharmacy, Immunology, Pharmacokinetics +12

Antibody-Mediated Coengagement of FcγRIIb and B Cell Receptor Complex Suppresses Humoral Immunity in Systemic Lupus Erythematosus

Holly M. Horton, Seung Y. Chu, Elizabeth Ortiz et al. · The Journal of Immunology · 2011 · 144 citations

Life Sciences, Immunology, Pathobiology +17

Dimerization via Tandem Leucine Zippers Is Essential for the Activation of the Mitogen-activated Protein Kinase Kinase Kinase, MLK-3

Irene Leung, Norman J. Lassam · Journal of Biological Chemistry · 1998 · 128 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

Marjorie Robbins, Mingjie Li, Irene Leung et al. · Nature Biotechnology · 2006 · 103 citations

Life Sciences, Genetics, Molecular Biology +15

The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates

Jonathan Zalevsky, Irene Leung, Sher Karki et al. · Blood · 2008 · 101 citations · Full text

Life Sciences, Immunology, Pathology +17