Amita Datta‐Mannan

Monoclonal Antibody Clearance

Amita Datta‐Mannan, Derrick R. Witcher, Ying Tang et al. · Journal of Biological Chemistry · 2006 · 162 citations · Full text

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

Amita Datta‐Mannan, Arunkumar Thangaraju, Donmienne Leung et al. · mAbs · 2015 · 143 citations · Full text

Immunology, Immunodominance, Peptide Science +28

Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates

Amita Datta‐Mannan, Derrick R. Witcher, Ying Tang et al. · Drug Metabolism and Disposition · 2006 · 130 citations

Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells

Nancy Goebl, Clifford M. Babbey, Amita Datta‐Mannan et al. · Molecular Biology of the Cell · 2008 · 102 citations · Full text

Immunology, Igg Internalization, Extracellular Microvesicles +17

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

Amita Datta‐Mannan, Jirong Lu, Derrick R. Witcher et al. · mAbs · 2015 · 82 citations · Full text

Immunocytochemical Technique, Immunology, Immunotherapy +16