Monoclonal Antibody Clearance

Amita Datta‐Mannan, Derrick R. Witcher, Ying Tang, +2

Journal of Biological Chemistry

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

Amita Datta‐Mannan, Arunkumar Thangaraju, Donmienne Leung, +4

mAbs

ImmunologyImmunodominancePeptide SciencePharmacotherapyAnalytical Ultracentrifugation +26

Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates

Amita Datta‐Mannan, Derrick R. Witcher, Ying Tang, +3

Drug Metabolism and Disposition

Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells

Nancy Goebl, Clifford M. Babbey, Amita Datta‐Mannan, +3

Molecular Biology of the Cell

ImmunologyIgg InternalizationExtracellular MicrovesiclesFcrn-dependent InternalizationCellular Physiology +15

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

Amita Datta‐Mannan, Jirong Lu, Derrick R. Witcher, +3

mAbs

Immunocytochemical TechniqueImmunologyImmunotherapyImmunochemistryAntibody Engineering +14

Follistatin: A Novel Therapeutic for the Improvement of Muscle Regeneration

Benjamin C. Yaden, Johnny E. Croy, Yan Wang, +8

Journal of Pharmacology and Experimental Therapeutics

FcRn Affinity-Pharmacokinetic Relationship of Five Human IgG4 Antibodies Engineered for Improved In Vitro FcRn Binding Properties in Cynomolgus Monkeys

Amita Datta‐Mannan, Chi-Kin Chow, Craig D. Dickinson, +4

Drug Metabolism and Disposition

Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies

Amita Datta‐Mannan, Selina Estwick, Zhou Chen, +6

mAbs

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys

Amita Datta‐Mannan, Derrick R. Witcher, Jirong Lu, +1

mAbs

Improved Fcrn BindingImmunocytochemical TechniqueVivo Half-lifeImmunologyImmunotherapeutics +16

Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys

Amita Datta‐Mannan, Johnny E. Croy, Linda Schirtzinger, +3

mAbs

ImmunologyImmunotherapyTranslational MedicineCynomolgus MonkeysImmunochemistry +15