Concepedia

Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates

Amita Datta‐Mannan, Derrick R. Witcher, Ying Tang, Jeffry D. Watkins, Weidong Jiang, Victor J. Wroblewski

Drug Metabolism and Disposition · 2006 · 133 citations · 33 references

DOI

Concepts

References

33

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

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[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

Thomas A. Kunkel, John D. Roberts, Richard A. Zakour · Methods in enzymology on CD-ROM/Methods in enzymology · 1987 · 5.3K citations

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Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

J. Deisenhofer · PubMed · 1981 · 1.4K citations

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Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

J. Deisenhofer · Biochemistry · 1981 · 1.3K citations

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High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Robert L. Shields, Angela K. Namenuk, Kyu Hong et al. · Journal of Biological Chemistry · 2001 · 1.2K citations · Full text

, , +17