Concepedia

Class Switch Recombination Defects

Class Switch Recombination Defects is a pathological impairment in the immunoglobulin class switch recombination process, characterized by failures in DNA recombination at the switch regions of the immunoglobulin heavy chain locus that prevent B cells from producing antibodies of different isotypes while retaining the same antigen specificity.

168

Publications

16.1K

Citations

1.2K

Authors

450

Institutions

Publications per year

2017–2026

20

Variants

Csr Defects

Parents

Publications

168

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan et al. · Cell · 2000 · 3.4K citations

, , +14

Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

Kohsuke Imai, Geir Slupphaug, Wen-I Lee et al. · Nature Immunology · 2003 · 625 citations

, , +12

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

Gunnar Schotta, Roopsha Sengupta, Stefan Kubicek et al. · Genes & Development · 2008 · 460 citations · Full text

, , +17

Constitutive Expression of AID Leads to Tumorigenesis

Il‐mi Okazaki, Hiroshi Hiai, Naoki Kakazu et al. · The Journal of Experimental Medicine · 2003 · 434 citations · Full text

, , +17

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

Ramsay Fuleihan, N Ramesh, Richard Loh et al. · Proceedings of the National Academy of Sciences · 1993 · 371 citations

, , +17

1–5 of 168

Authors

1.2K

  1. AD
    Anne Durandy

    Inserm, France

    10 publications · 1.1K citations

    10

    h-index

  2. TH
    Tasuku Honjo

    Kyoto University, Japan

    9 publications · 4.5K citations

    9

    h-index

  3. QP
    Qiang Pan‐Hammarström

    Karolinska Institutet, Sweden

    9 publications · 788 citations

    9

    h-index

  4. MC
    Michel C. Nussenzweig

    Rockefeller University, United States

    7 publications · 1.3K citations

    7

    h-index

  5. MC
    Michel Cogné

    Centre National de la Recherche Scientifique, France

    6 publications · 308 citations

    6

    h-index

1–5 of 1.2K

Institutions

450

  1. Inserm

    Paris, France

    14 h-index

    58 publications

    6.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    44 publications

    7.3K citations

  3. National Institutes of Health

    Bethesda, United States

    12 h-index

    63 publications

    6.8K citations

  4. Kyoto University

    Kyoto, Japan

    11 h-index

    60 publications

    29.1K citations

  5. Karolinska Institutet

    Stockholm, Sweden

    11 h-index

    44 publications

    2.8K citations

  6. Karolinska University Hospital

    Stockholm, Sweden

    10 h-index

    42 publications

    3K citations

  7. Université Paris Cité

    Paris, France

    10 h-index

    33 publications

    2.2K citations

  8. National Cancer Institute

    Bethesda, United States

    9 h-index

    30 publications

    5K citations

1–8 of 450

Venues

  1. The Journal of Immunology

    JI · 33 publications · 1.9K citations

    23

    h-index

  2. The Journal of Experimental Medicine

    20 publications · 2.8K citations

    20

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 1.5K citations

    12

    h-index

  4. Blood

    9 publications · 545 citations

    9

    h-index

  5. PLoS ONE

    7 publications · 196 citations

    7

    h-index

1–5