Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

Patrick Revy, Taro Muto, Yves Lévy et al. · Cell · 2000 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

Masamichi Muramatsu, V.S. Sankaranand, Shrikant Anant et al. · Journal of Biological Chemistry · 1999 · 1.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Intraclonal generation of antibody mutants in germinal centres

Joshy Jacob, Garnett Kelsoe, Klaus Rajewsky · Nature · 1991 · 1.1K citations

Life Sciences, Genetics, Immunology +10

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

Hua Gu, Yong‐Rui Zou, Klaus Rajewsky · Cell · 1993 · 999 citations

Life Sciences, Genetics, Molecular Biology +16

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

R.Cutler Allen, Richard J. Armitage, Mary Ellen Conley et al. · Science · 1993 · 827 citations

Life Sciences, Genetics, Immunology +17