Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan, +3

Cell

Natural SciencesGeneticsRna BiologyMolecular BiologyGene Editing +5

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

Patrick Revy, Taro Muto, Yves Lévy, +18

Cell

Mendelian DisorderAutoimmune DiseaseGenetic DisorderGeneticsImmunology +6

Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

Masamichi Muramatsu, V.S. Sankaranand, Shrikant Anant, +4

Journal of Biological Chemistry

Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors

Seiichi Hirota, Akiko Ohashi, Toshirou Nishida, +4

Gastroenterology

Cancer ResearchGastrointestinal OncologyBlood PlateletGastrointestinal Stromal TumorsPathology +6

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

Yuko Matsumoto, Hiroyuki Marusawa, Kazuo Kinoshita, +7

Nature Medicine

Gastrointestinal PharmacologyPathogenesisGastroenterologyPathologyClinical Gastroenterology +6

Constitutive Expression of AID Leads to Tumorigenesis

Il‐mi Okazaki, Hiroshi Hiai, Naoki Kakazu, +4

The Journal of Experimental Medicine

Cancer ResearchImmunogeneticsGenome StabilitySomatic VariantAllergy +13

Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut

Masayuki Tsuji, Keiichiro Suzuki, Hiroshi Kitamura, +6

Immunity

InflammationAutoimmune DiseaseMucosal ImmunologyLymphoid Tissue-inducer CellsLymphocyte Development +8

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

Sidonia Fagarasan, Kazuo Kinoshita, Masamichi Muramatsu, +2

Nature

BiologyCell LineageDevelopmental BiologyCell DivisionGut Lamina Propria +9

AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts

Kiyotsugu Yoshikawa, Il‐mi Okazaki, Tomonori Eto, +4

Science

GeneticsMolecular BiologyMolecular GeneticsTranscriptional RegulationGene Transfer +14

AID mutant analyses indicate requirement for class-switch-specific cofactors

Van-Thanh Ta, Hitoshi Nagaoka, Nadia Catalan, +10

Nature Immunology

GeneticsMolecular BiologyGenetic MechanismMolecular GeneticsMedicine +2