Concepedia

Base Editing Specificity

Base Editing Specificity is the extent to which a base editing system accurately modifies only the intended target nucleotide without inducing off-target or unintended edits within the genome.

48

Publications

10.3K

Citations

400

Authors

130

Institutions

Publications per year

2017–2026

48

Parents

Publications

48

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees et al. · Nature · 2017 · 4.2K citations · Full text

, , +12

Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

Zhen Liu, Zongyang Lu, Guang Yang et al. · Nature Communications · 2018 · 2.1K citations · Full text

, , +16

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Alexis C. Komor, Kevin T. Zhao, Michael S. Packer et al. · Science Advances · 2017 · 784 citations · Full text

, , +16

Continuous evolution of base editors with expanded target compatibility and improved activity

B W. Thuronyi, Luke W. Koblan, Jonathan M. Levy et al. · Nature Biotechnology · 2019 · 345 citations · Full text

, , +7

Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning

Mandana Arbab, Max W. Shen, Beverly Mok et al. · Cell · 2020 · 292 citations · Full text

, , +11

1–5 of 48

Authors

400

  1. DR
    David R. Liu

    Harvard University, United States

    5 publications · 5.7K citations

    5

    h-index

  2. SC
    Siyu Chen

    Jilin University, China

    4 publications · 166 citations

    4

    h-index

  3. XH
    Xingxu Huang

    ShanghaiTech University, China

    4 publications · 2.4K citations

    4

    h-index

  4. ZL
    Zhiquan Liu

    Jilin University, China

    4 publications · 166 citations

    4

    h-index

  5. ZL
    Zhanjun Li

    Jilin University, China

    4 publications · 166 citations

    4

    h-index

1–5 of 400

Institutions

130

  1. Chinese Academy of Sciences

    Beijing, China

    15 h-index

    51 publications

    10.3K citations

  2. University of Chinese Academy of Sciences

    Beijing, China

    8 h-index

    20 publications

    3.4K citations

  3. Broad Institute

    Cambridge, United States

    7 h-index

    44 publications

    41.1K citations

  4. ShanghaiTech University

    Shanghai, China

    5 h-index

    32 publications

    23.5K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    26 publications

    38.1K citations

  6. Harvard University

    Cambridge, United States

    5 h-index

    37 publications

    42.5K citations

  7. Center for Excellence in Molecular Cell Science

    Shanghai, China

    5 h-index

    7 publications

    3.1K citations

  8. Guangzhou Regenerative Medicine and Health Guangdong Laboratory

    Guangzhou, China

    4 h-index

    4 publications

    166 citations

1–8 of 130

Venues

  1. Nature Communications

    9 publications · 2.6K citations

    9

    h-index

  2. Nature Biotechnology

    7 publications · 921 citations

    7

    h-index

  3. Molecular Therapy — Nucleic Acids

    3 publications · 47 citations

    3

    h-index

  4. Science Advances

    3 publications · 951 citations

    3

    h-index

  5. BMC Biology

    2 publications · 85 citations

    2

    h-index

1–5